murphyCyclohexasiloxane
AKA: Silicone
Synthetic
Emollient
Solvent
Skin Conditioner
Hair Care
Not Clean
OriginDerived from siloxane compounds, a class of silicon-oxygen polymers synthesized from inorganic materials. Produced through cyclization and polymerization of dimethyldichlorosilane monomers under controlled catalytic conditions.
Dodecamethylcyclohexasiloxane
Formula
C12H36O6Si6
Mol. Weight
444.92
CAS #
540-97-6
Form
Liquid
State
Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
3
CIR
Safe as used
Pregnancy
Yes
Restricted By
CIR Safety Findings
Not a Sensitizer
1 study / 1 not sensitizing (CIR 497)
Eye Irritant in Testing
1 study / 1 irritating (CIR 497)
Mixed Skin Irritation Results
2 studies / 1 irritating / 1 not irritating (CIR 497)
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR