Diethyl Malonate

AKA: 105-53-3, Diethyl propanedioate, Malonic ester, Propanedioic acid, Diethyl ester, 1, 3-diethyl propanedioate, Carbethoxyacetic ester, Malonic acid, Dicarbethoxymethane
Synthetic
Fragrance
Clean
OriginDerived from malonic acid and ethanol, belonging to the ester chemical family. Synthesized through esterification of malonic acid with ethanol under acidic catalysis.
isomer of diethylmalonic acid; one of most used compounds in drug synthesis, don't confuse with ethylmalonic acid
Solubility In water, 20 g/L at 20 °C
Formula
C7H12O4
Mol. Weight
160.17
CAS #
105-53-3
Form
Liquid
State
Liquid, Other Solid; Liquid
Skin Types
●all-skin-types
Best For
General
Functions
Perfuming
Added for scent. Can be natural or synthetic. Common irritant and allergen — one of the top reasons people react to products.
Adds Fragrance
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
—
CIR Safety Findings
Eye Irritant in Testing
1 study / 1 irritating / reactions slight to moderate (CIR 528)
Skin Irritant in Testing
1 study / 1 irritating / reactions slight (CIR 528)
Dermal Absorption 0.2–16%
5 lab (in vitro) studies in the CIR safety assessment (CIR 528)
Concentration Guide
Leave-on0.02%
Rinse-off0.004–0.01%
0%50%100%
CIR reported use · report published 2012
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR