Diethyl Malonate

AKA: 105-53-3, Diethyl propanedioate, Malonic ester, Propanedioic acid, Diethyl ester, 1, 3-diethyl propanedioate, Carbethoxyacetic ester, Malonic acid, Dicarbethoxymethane
Synthetic
Fragrance
Clean
isomer of diethylmalonic acid; one of most used compounds in drug synthesis, don't confuse with ethylmalonic acid
Solubility In water, 20 g/L at 20 °C
Formula
C7H12O4
Mol. Weight
160.17
CAS #
105-53-3
Form
Liquid
State
Liquid, Other Solid; Liquid
Functions
Perfuming
Added for scent. Can be natural or synthetic. Common irritant and allergen — one of the top reasons people react to products.
Adds Fragrance
Traditional Use
Modern synthetic compound developed for use as a solvent and conditioning agent in cosmetic formulations. Created to provide improved stability and texture in personal care products.
EWG
1
CIR
Safe as used
Pregnancy
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
General
The paper trail
🔬Peer-reviewed1 paper
⚖️Regulatory1 listing
🛡️Safety-assessed1 review
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR