murphyDiethyl Sebacate
AKA: Diethyl decanedioate, 110-40-7, Decanedioic acid, Diethyl ester, Bisoflex DES, Sebacic acid, Sebacic acid diethyl ester, 1, 10-diethyl decanedioate, FEMA No. 2376
Synthetic
Emollient
Solvent
Skin Conditioner
Clean
OriginDerived from sebacic acid and ethanol, both petroleum-derived or synthesized from castor oil feedstocks. Produced through esterification reaction between sebacic acid and ethanol under catalytic conditions.
Diethyl decanedioate is a fatty acid ester.
Solubility 0.08 mg/mL at 20 °C
Formula
C14H26O4
Mol. Weight
258.35
CAS #
110-40-7
Form
Liquid
State
Colorless to yellowish liquid; [Merck Index] Clear colorless liquid; [Sigma-Aldrich MSDS]
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Plasticiser
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
1 study / 1 not sensitizing / plus 2 case reports (CIR 528)
Mixed Skin Irritation Results
3 studies / 1 mixed / 2 not irritating / reactions weak (CIR 528)
Concentration Guide
Leave-on1.5%
Rinse-offNot reported
0%50%100%
CIR reported use · 2010 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR