murphyDiisopropyl Sebacate
AKA: 7491-02-3, Decanedioic acid, Bis(1-methylethyl) ester, Bis(1-methylethyl)decanedioate, DERMOL DIPS, Bis(1-methylethyl) decanedioate
Synthetic
Emollient
Solvent
Skin Conditioner
Clean
OriginSynthesized from sebacic acid and isopropanol, both petroleum-derived chemical compounds. Produced through acid-catalyzed esterification, combining the two reactants under heat and catalytic conditions.
vehicle in topical anti-acne lotion; implicated in contact dermatitis; structure given in first source
Formula
C16H30O4
Mol. Weight
286.41
CAS #
7491-02-3
Form
Liquid
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Plasticiser
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
4 studies / 4 not sensitizing / plus 1 case report (CIR 528)
Eye Irritant in Testing
1 study / 1 irritating / reactions minimal (CIR 528)
Mixed Skin Irritation Results
6 studies / 1 mixed / 5 not irritating / reactions mild (CIR 528)
Concentration Guide
Leave-on0.06–10%
Rinse-off2%
0%50%100%
CIR reported use · 2010 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR