Dimethyl Succinate

AKA: 106-65-0, Dimethyl butanedioate, Dimethylsuccinate, Butanedioic acid, Dimethyl ester, Succinic acid, Methyl butanedioate, FEMA No. 2396, 1, 4-dimethyl butanedioate
Synthetic
Emollient
Solvent
Skin Conditioner
Clean
OriginDerived from succinic acid, a four-carbon dicarboxylic acid produced through fermentation or petroleum-based synthesis. Synthesized through esterification of succinic acid with methanol using catalytic conditions.
Dimethyl succinate has been reported in Astragalus mongholicus and Astragalus membranaceus with data available.
Solubility greater than or equal to 100 mg/mL at 73 °F (NTP, 1992)
Formula
C6H10O4
Mol. Weight
146.14
CAS #
106-65-0
Form
Liquid
State
Dimethyl succinate is a colorless liquid. (USCG, 1999)
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
2
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
Leave-on0.002%
Rinse-off0.2–5%
0%50%100%
CIR reported use · report published 2012
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR