Disodium Glycyrrhizate

AKA: 71277-79-7, Disodium glycyrrhizin, CCRIS 1966, Glycyrrhizinic acid disodium salt, DISODIUM GLYCYRRHIZATE [WHO-DD], Alpha-D-Glucopyranosiduronic acid, Disodium salt
Synthetic
Skin Conditioner
Not Clean
OriginDerived from glycyrrhizin, the active compound isolated from licorice root (Glycyrrhiza glabra). Synthesized through neutralization of glycyrrhizin with sodium hydroxide to create the disodium salt form.
.alpha.-D-Glucopyranosiduronic acid (3.beta., 20.beta.)-20 -carboxy-11-oxo-30-norolean-12-en-3-yl 2-0-.beta.-D-glucopyranurosyl-, disodium salt
Formula
C42H59Na2O16-
Mol. Weight
865.90
CAS #
71277-79-7
Form
Powder
Skin Types
●all-skin-types
Best For
Redness
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Brightens uneven skin tone
Evens pigmentation
Quells irritation
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic (CIR Panel on the ingredient group)
CIR Panel statement covering this group of ingredients; not tested individually (CIR 349)
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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