murphyDMDM Hydantoin
AKA: 6440-58-0, Glydant, 1, 3-Bis(hydroxymethyl)-5, 5-dimethylhydantoin, 3-Dimethylol-5, Dantoin-DMDMH, Glycoserve-DMDMH, Dantoin dmdmh 55, Dimethylol-5
Synthetic
Preservative
Not Clean
OriginSynthesized from formaldehyde and dimethylol compounds, belonging to the hydantoin chemical family of preservatives. Produced through condensation reaction of formaldehyde with dimethylhydantoin under controlled conditions.
1,3-bis(Hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione
Solubility In water, 77.3 g/100 cc
Formula
C7H12N2O4
Mol. Weight
188.18
CAS #
6440-58-0
Form
Liquid
State
Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Allergen Warning
⚠️ Formaldehyde Releaser
Functions
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Preserves Formula
Antioxidant Protection
Reduces Inflammation
Locks In Moisture
Prevents microbial growth
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
6
CIR
Safe as used
Pregnancy
Caution
Restricted By
CIR Safety Findings
Not Phototoxic
Human test and Product formulation test found no phototoxicity in the CIR safety assessment (CIR 154)
Mixed Eye Irritation Results
4 studies / 1 irritating / 3 not irritating / reactions minimal (CIR 154)
Mixed Skin Irritation Results
13 studies / 7 irritating / 2 mixed / 4 not irritating / reactions slight to moderate (CIR 154)
Mixed Sensitization Results
5 studies / 1 sensitizing / 4 not sensitizing / reactions mild (CIR 154)
Concentration Guide
0%50%100%
Reg. limit 0.6%
EU regulatory limit: 0.6%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex V (Preservatives), Entry 33.
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR