murphyEthanolamine
AKA: 2-aminoethanol, 141-43-5, Monoethanolamine, 2-Aminoethan-1-ol, 2-Hydroxyethylamine, Colamine, Aminoethanol
Synthetic
Not Clean
OriginSynthesized from ammonia and ethylene oxide, members of the amine chemical family. Produced through the reaction of ethylene oxide with aqueous ammonia under controlled conditions.
Monoethanolamine is a first generation monoethanolamine with antihistaminic property. Ethanolamine competes with free histamine for binding at the histamine (H)-1 receptor thereby acting as an inverse agonist that combines with and stabilizes the inactive form of the H1-receptor thereby shifting the equilibrium toward the inactive state. This leads to a reduction of the negative symptoms brought on by H1-receptor binding.
Solubility greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)
Formula
C2H7NO
Mol. Weight
61.08
CAS #
141-43-5
Form
Liquid
State
Ethanolamine appears as a clear colorless liquid with an odor resembling that of ammonia. Flash point 185 °F. May attack copper, brass, and rubber. Corrosive to tissue. Moderately toxic. Produces toxi
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Buffering
Stabilizes pH
Antioxidant Protection
Reduces Inflammation
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
6
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Eye Irritant in Testing
4 studies / 4 irritating / reactions slight to severe (CIR 217 and 604)
Skin Irritant in Testing
7 studies / 7 irritating / reactions mild to corrosive / plus 1 case report (CIR 217 and 604)
Mixed Sensitization Results
4 studies / 1 sensitizing / 1 mixed / 2 not sensitizing / plus 6 case reports (CIR 217 and 604)
Dermal Absorption 0.61–24.79%
8 lab (in vitro) studies in the CIR safety assessment (CIR 604)
Concentration Guide
Leave-onNot reported
Rinse-off0.0002–18%
0%50%100%
CIR reported use · report published 2015
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR