Fumaric Acid

AKA: 110-17-8, Trans-Butenedioic acid, Allomaleic acid, Lichenic acid, Boletic acid, (2E)-but-2-enedioic acid, Tumaric acid, Trans-1, 2-Ethylenedicarboxylic acid, (E)-2-Butenedioic acid
Plant-Derived Synthetic
Acid
Clean
OriginDerived from fumaric acid naturally occurring in plants of the Papaveraceae family, particularly fumitory species. Produced synthetically through maleic anhydride isomerization or fermentation of carbohydrates by specific microorganisms.
Fumaric acid is a precursor to L-malate in the Krebs tricarboxylic acid cycle. It is formed by the oxidation of succinate by succinate dehydrogenase. Fumarate is converted by fumarase to malate. A fumarate is a salt or ester of the organic compound fumaric acid, a dicarboxylic acid. Fumarate has recently been recognized as an oncometabolite. (A15199). As a food additive, fumaric acid is used to impart a tart taste to processed foods. It is also used as an antifungal agent in boxed foods such as cake mixes and flours, as well as tortillas. Fumaric acid is also added to bread to increase the porosity of the final baked product. It is used to impart a sour taste to sourdough and rye bread. In cake mixes, it is used to maintain a low pH and prevent clumping of the flours used in the mix. In fruit drinks, fumaric acid is used to maintain a low pH which, in turn, helps to stabilize flavor and color. Fumaric acid also prevents the growth of E. coli in beverages when used in combination with s
Solubility less than 1 mg/mL at 72 °F (NTP, 1992)
Formula
C4H4O4
Mol. Weight
116.07
CAS #
110-17-8
Form
Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Buffering
Stabilizes pH
Fights Bacteria
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
2 studies / 2 not sensitizing (CIR 464)
Eye Irritant in Testing
2 studies / 2 irritating / reactions moderate (CIR 464)
Mixed Skin Irritation Results
3 studies / 1 irritating / 2 not irritating / reactions slight / plus 1 case report (CIR 464)
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR