murphyGluconic Acid
AKA: D-gluconic acid, 526-95-4, Dextronic acid, Maltonic acid, Glycogenic acid, (2R, 3S, 4R, 5R)-2, 3, 4, 5, 6-pentahydroxyhexanoic acid, Glosanto, Pentahydroxycaproic acid, D-Gluco-hexonic acid
Synthetic
Skin Conditioner
Acid
Clean
OriginGluconic acid is produced through the oxidation of glucose, a simple sugar derived from corn or other carbohydrate sources. It is synthesized via fermentation or chemical oxidation of glucose using microorganisms or oxidizing agents.
Gluconic Acid is the carboxylic acid formed by the oxidation of the first carbon of glucose with antiseptic and chelating properties. Gluconic acid, found abundantly in plant, honey and wine, can be prepared by fungal fermentation process commercially. This agent and its derivatives can used in formulation of pharmaceuticals, cosmetics and food products as additive or buffer salts. Aqueous gluconic acid solution contains cyclic ester glucono delta lactone structure, which chelates metal ions and forms very stable complexes. In alkaline solution, this agent exhibits strong chelating activities towards anions, i.e. calcium, iron, aluminium, copper, and other heavy metals.
Solubility FREELY SOL IN WATER; SLIGHTLY SOL IN ALC, INSOLUBLE IN ETHER AND MOST OTHER ORGANIC SOLVENTS
Formula
C6H12O7
Mol. Weight
196.16
CAS #
526-95-4
Form
Liquid
State
NKRA; Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Buffering
Removes Metal Ions
Adds Fragrance
Adds pleasant scent
Binds metal ions
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory0 listings
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
1 study / 1 not irritating (CIR 657)
Mixed Eye Irritation Results
1 study / 1 mixed / reactions slight (CIR 657)
Concentration Guide
Leave-on0.0001–0.18%
Rinse-offNot reported
0%50%100%
CIR reported use · report published 2019
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR