Glucosamine
molecular structure · PubChem
AKA: D-glucosamine, 2-amino-2-deoxy-D-glucopyranose, Chitosamine, (3R, 4R, 5S, 6R)-3-amino-6-(hydroxymethyl)oxane-2, 4, 5-triol, Glucosamina, Mediflex, 2-Deoxy-2-amino-D-glucose, CHEBI:47977
Synthetic
Skin Conditioner
Hair Care
Clean
Glucosamine is a cosmetic ingredient used as antistatic, hair conditioning. Rated low hazard by EWG.
Solubility 330 mg/mL
Formula
C6H13NO5
Mol. Weight
179.17
CAS #
3416-24-8
Form
Liquid
State
Alpha and beta forms are solids; [Merck Index]
Functions
Antistatic
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Quells irritation
Reduces redness
Reduces swelling
Traditional Use
Discovered in crustacean shells in the early 20th century; historically used in traditional medicine for joint health. Modern research in the 1980s-1990s led to its adoption in skincare for its role in maintaining skin structure and hydration.
EWG
1
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
medical-approval
all-shades-safe
Dermal Absorption 5%
Concentration Guide
Dermal absorption: 5%. Source: CIR Safety Assessment (CIR Seq 832).
Regulatory Agencies
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Caution
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR