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Glucosamine HCL
AKA “D-Glucosamine hydrochloride, (2R, 3R, 4S, 5R)-2-amino-3, 4, 5, 6-tetrahydroxyhexanal hydrochloride, Cosamin, D-Glucose, 2-amino-2-deoxy-, hydrochloride, Chitosamine hydrochloride, D-Glucosamine chloride, 2-Amino-2-deoxy-D-glucose hydrochloride, Artrox (TN), D-Glucosamine monohydrochloride, NSC 758”
Synthetic
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Ingredient Facts
Glucosamine hcl
AKA: D-Glucosamine hydrochloride, (2R, 3R, 4S, 5R)-2-amino-3, 4, 5, 6-tetrahydroxyhexanal hydrochloride, D-Glucose, 2-amino-2-deoxy-, Hydrochloride, Chitosamine hydrochloride, D-Glucosamine chloride, 2-Amino-2-deoxy-D-glucose hydrochloride, Artrox (TN), D-Glucosamine monohydrochloride, NSC 758
Synthetic · Skin Conditioning · EWG: 1
Synthetic
Skin Conditioner
Synthetic
Clean
The Expert Panel for Cosmetic Ingredient Safety concluded that Glucosamine HCl is safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating.
Formula
C6H14ClNO5
Mol. Weight
215.63
CAS #
66-84-2
Form
Liquid
State
White powder; [Alfa Aesar MSDS]
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Reduces Static
Conditions Hair
Reduces flyaways
Softens and detangles hair
Traditional Use
Not a recognized cosmetic ingredient. This designation may refer to a company code or internal reference rather than a standardized ingredient.
Skin Types
●all-skin-types
Best For
General
EWG
1
CIR
Insufficient
Pregnancy
—
CIR Safety Findings
all-shades-safe
Dermal Absorption 5%
Concentration Guide
Dermal absorption: 5%. Source: CIR Safety Assessment (CIR Seq 832).
Regulatory Status
USAunder review
CANADA✔ permitted
Regulatory Agencies
Glucosamine.
T S Barclay, C Tsourounis, G M McCart
The Annals of pharmacotherapy, 1998
→
Transdermal co-delivery of glucosamine sulfate and diacerein for the induction of chondroprotection in experimental osteoarthritis.
Chattopadhyay H, Auddy B, Sur T, Gupta M, Datta S
Drug delivery and translational research, 2020
→
Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2,4-Diaminophenol and 2,4-Diaminophenol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of 2,4-Diaminophenoxyethanol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Chlorhexidine/Chlorhexidine Diacetate/Chlorhexidine Dihydrochloride/Chlorhexidine Digluconate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of N-Phenyl-p-Phenylenediamine, N-Phenyl-p-Phenylenediamine Hydrochloride, and N-Phenyl-p-Phenylenediamine Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Note Regarding the Safety Assessment of Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, and Chlorhexidine Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Glucosamine Ingredients as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Polyaminopropyl Biguanide (polyhexamethylene biguanide hydrochloride) as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Chlorhexidine Dihydrochloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glucosamine
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glucosamine Sulfate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
TEA-Hydrochloride
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Safety and efficacy of l-histidine monohydrochloride monohydrate produced using Corynebacterium glutamicum KCCM 80179 for all animal species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, de Lourdes Bastos M, Christensen H et al.
EFSA journal. European Food Safety Authority, 2019
→
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCC
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H et al.
EFSA journal. European Food Safety Authority, 2020
→
Acetyl Glucosamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Chlorhexidine Dihydrochloride
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Disodium Acetyl Glucosamine Phosphate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glucosamine
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glucosamine HCL
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glucosamine Sulfate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Safety Assessment of Glucosamine Ingredients as Used in Cosmetics.
Ferguson P, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2026
→
Transdermal permeability of N-acetyl-D-glucosamine.
Garner ST Jr, Israel BJ, Achmed H, Capomacchia AC, Abney T et al.
Pharmaceutical development and technology, 2007
→
Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers.
Gwak HS, Oh IS, Chun IK
Drug development and industrial pharmacy, 2004
→
Chrysoidine citrate hydrochloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Diphenoxylate hydrochloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Safety Assessment of Polyaminopropyl Biguanide (Polyhexamethylene Biguanide Hydrochloride) as Used in Cosmetics.
Johnson W Jr, Boyer I, Zhu J, Bergfeld WF, Belsito DV et al.
International journal of toxicology, 2020
→
Chlorhexidine Dihydrochloride Shows Anti-tumor Effects in Desmoid Tumors and Colorectal Cancer.
Shin H, Kim Y, Lee Y, Kim J, Ryu YC et al.
Anticancer research, 2024
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR