Glyceryl Di-Hydroxystearate

AKA: 122546-20-7, 2, 3-dihydroxypropyl 2, 2-dihydroxyoctadecanoate

Plant-Derived

Emollient

Skin Conditioner

Not Clean

12-Hydroxyoctadecanoic Acid, 2-Hydroxy-1,3-Propanediyl,2-Hydroxy-1,3-Propanediyl 12-Hydroxyoctadecanoate,2'-Hydroxy-1',3'-propylene 12-hydroxystearate,Hydroxystearic Acid, Diester with 1,2,3-Propanetriol,Octadecanoic Acid, 12-Hydroxy-, 2-Hydroxy-1,3-Propanediyl Ester

Formula

C21H42O6

Mol. Weight

390.60

CAS #

122546-20-7

Form

Liquid

Functions

Skin Conditioning

A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.

Emollient

Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.

Locks In Moisture

Traditional Use

Variant spelling of the same synthetic compound used as a cosmetic thickener and texture modifier without traditional precedent.

EWG

CIR

Safe as used

Pregnancy

Yes

CIR Safety Findings

Not a Sensitizer

medical-approval

all-shades-safe

Regulatory Status

USA✔ permitted

EU⚠ restricted

JAPAN⚠ restricted

CANADA⚠ restricted

Regulatory Agencies

EWG CIR FDA EU COSING Health Canada

Skin Types

●all-skin-types

Best For

Dryness

Pregnancy & Breastfeeding Safe

Yes

The paper trail

🔬Peer-reviewed1 paper →

⚖️Regulatory1 listing →

🛡️Safety-assessed1 review →

Counts, not a verdict. A listing isn't a study. The trail, you decide.

Verified Jun 2026

Data: PubChem · CosIng · EWG · CIR