Glyceryl Isostearate

AKA: Glyceryl monoisostearate, Glycerol monoisostearate, 66085-00-5, Glycerin monoisostearate, NIKKOL MGIS, GLYCEROISOSTEARATE, Isooctadecanoic acid, Monoester with 1, 2, 3-propanetriol
Plant-Derived
Emollient
Cleanser
Emulsifier
Skin Conditioner
Not Clean
OriginDerived from isostearic acid and glycerin, typically sourced from synthetic or plant-based fatty acids. Produced through esterification of glycerin with isostearic acid using catalytic methods.
Isooctadecanoic acid, monoester with glycerol
Formula
C21H42O4
Mol. Weight
358.60
CAS #
66085-00-5, 32057-14-0
Form
Liquid
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Locks In Moisture
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
Animal test found no phototoxicity in the CIR safety assessment (CIR 320)
Mixed Eye Irritation Results
5 studies / 1 mixed / 4 not irritating (CIR 320 and 344 and 706)
Mixed Skin Irritation Results
3 studies / 1 irritating / 1 mixed / 1 not irritating / reactions slight to moderate (CIR 320 and 344)
Sensitizer in Testing
1 study / 1 sensitizing / plus 3 case reports (CIR 320 and 344 and 706)
Concentration Guide
Leave-on0.8–2%
Rinse-off0.3–1.5%
0%50%100%
CIR reported use · 2014 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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