Glycyrrhetinic Acid

AKA: Enoxolone, Glycyrrhetic acid, Uralenic acid, 471-53-4, 18-beta-Glycyrrhetinic acid, Enoxolona, 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid, Enoxolonum
Synthetic
Skin Conditioner
Acid
Not Clean
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta., 20.beta.)-
Formula
C30H46O4
Mol. Weight
470.70
CAS #
471-53-4
Form
Liquid
State
Solid
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
The active triterpene compound extracted from licorice root, isolated and studied extensively in the 1970s-1980s. Used in skincare for anti-inflammatory and skin-soothing properties, building on licorice's traditional use in Asian medicine.
EWG
3
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not an Irritant
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
Redness
Pregnancy & Breastfeeding Safe
Caution
The paper trail
🔬Peer-reviewed1 paper
⚖️Regulatory1 listing
🛡️Safety-assessed2 reviews
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR