HC Orange No. 1

HC Orange No. 1 1
molecular structure · PubChem CID 3846708
AKA: 54381-08-7, 4-((2-Nitrophenyl)amino)phenol, HC Orange 1, Phenol, 2-Nitro-4'-hydroxydiphenylamine, 4-[(2-nitrophenyl)amino]phenol, COLOREX HCO1
Synthetic
Not Clean
p-[(o-Nitrophenyl)amino]phenol
Formula
C12H10N2O3
Mol. Weight
230.22
CAS #
54381-08-7
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Hair Dyeing
Colors Hair
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory0 listings
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
3 studies / 3 not sensitizing (CIR 41)
Not Phototoxic
Animal test found no phototoxicity in the CIR safety assessment (CIR 41)
Eye Irritant in Testing
1 study / 1 irritating / reactions slight (CIR 41)
Mixed Skin Irritation Results
2 studies / 1 irritating / 1 not irritating (CIR 41)
Dermal Absorption 1.28–1.41%
2 results from in vitro tests in the CIR safety assessment (CIR 41)
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR