HC Red No. 1

AKA: 2-Nitro-4-aminodiphenylamine, 2784-89-6, 4-Benzenediamine, 4-Amino-2-nitrodiphenylamine, 2-Nitro-N-phenylbenzene-1, 4-diamine, 2-Nitro-N1-phenyl-1, 4-benzenediamine, 2-nitro-4-amino-n-phenylaniline
Synthetic
Not Clean
2-Nitro-N1-phenylbenzene-1,4-diamine
Formula
C12H11N3O2
Mol. Weight
229.23
CAS #
2784-89-6
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Hair Dyeing
Colors Hair
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory0 listings
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not Phototoxic
Animal test found no phototoxicity in the CIR safety assessment (CIR 12)
Eye Irritant in Testing
1 study / 1 irritating / reactions mild (CIR 12)
Mixed Skin Irritation Results
2 studies / 1 irritating / 1 not irritating (CIR 12)
Sensitizer in Testing
3 studies / 3 sensitizing (CIR 12)
Dermal Absorption 1.68%
human female cadaver skin / in vitro static Franz cell / 1% 14C-H.C. Red No. 1 in a commercial semipermanent dye base / 10 mg/cm2 for 30 min then rinsed / 48 h (CIR 12)
Concentration Guide
Leave-onNot reported
Rinse-off0.07%
0%50%100%
CIR reported use · 2011 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
murphy