Hexapeptide-12

AKA: 70592-18-6, Ala-pro-gly-val-gly-val, L-Valine, Hexapeptide-12 (ala-pro-gly-val-gly-val), Hexapeptide-12 (ala-pro-gly-val-gly-val) [INCI]
Synthetic
Skin Conditioner
Clean
Hexapeptide-12 is a synthetic peptide containing Alanine, Glycine, Proline and Valine residues
Formula
C22H38N6O7
Mol. Weight
498.60
CAS #
-
Form
Powder
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Boosts collagen production
Reduces fine lines
Traditional Use
A synthetic peptide developed in modern cosmetic research to mimic natural skin signaling molecules. Created to reduce facial muscle contractions and improve skin firmness without invasive procedures.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper
⚖️Regulatory1 listing
🛡️Safety-assessed2 reviews
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR