Histidine HCl

AKA: L-Histidine hydrochloride, 645-35-2, 1007-42-7, Histidine hydrochloride, Histidine monohydrochloride, L-Histidine, Monohydrochloride, L-Histidine monohydrochloride, L-Histidine hydrochloride (VAN)
Synthetic
Skin Conditioner
Hair Care
Clean
Histidine HCl is a cosmetic ingredient used as hair conditioning, skin conditioning. Also known as L-Histidine hydrochloride. Rated low hazard by EWG. Assessed as safe by the CIR.
Formula
C6H10ClN3O2
Mol. Weight
191.61
CAS #
645-35-2, 5934-29-2
Form
Powder
State
Fine white crystals; [Sigma-Aldrich MSDS]
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
The hydrochloride salt form of the amino acid histidine, developed for cosmetic formulations to improve stability and skin penetration. Used since the 1970s in anti-aging and moisturizing products.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not Phototoxic
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper
⚖️Regulatory1 listing
🛡️Safety-assessed2 reviews
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR