Hydroxyacetophenone

Hydroxyacetophenone 1
molecular structure · PubChem CID 7469
AKA: 4'-Hydroxyacetophenone, 99-93-4, 1-(4-Hydroxyphenyl)ethanone, 4-Hydroxyacetophenone, P-HYDROXYACETOPHENONE, 4-Acetylphenol, P-Hydroxyphenyl methyl ketone, Ethanone, Methyl p-hydroxyphenyl ketone, Para-Hydroxyacetophenone
Synthetic
Antioxidant
Clean
OriginSynthesized from acetophenone, a compound derived from benzene and acetic acid through organic chemistry. Produced via hydroxylation of acetophenone using oxidation reactions to introduce the hydroxyl group.
Ethanone, 1-(4-hydroxyphenyl)-,p-Hydroxyacetophenone
Solubility Practically insoluble or insoluble in water
Formula
C8H8O2
Mol. Weight
136.15
CAS #
99-93-4
Form
Powder
State
Dry Powder; Other Solid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Neutralizes Free Radicals
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
4 studies / 4 not sensitizing / plus 1 case report (CIR 835)
Mixed Skin Irritation Results
7 studies / 2 irritating / 5 not irritating / reactions slight (CIR 835)
Eye Irritant in Testing
3 studies / 3 irritating / reactions moderate to severe (CIR 835)
Concentration Guide
Leave-on0.02–5%
Rinse-off0.000099–5%
0%50%100%
CIR reported use · report published 2022
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR