Hydroxyacetophenone
AKA “4'-Hydroxyacetophenone, 99-93-4, 1-(4-Hydroxyphenyl)ethanone, 4-Hydroxyacetophenone, P-HYDROXYACETOPHENONE, 4-Acetylphenol, p-Hydroxyphenyl methyl ketone, Ethanone, 1-(4-hydroxyphenyl)-, Methyl p-hydroxyphenyl ketone, para-Hydroxyacetophenone”
Antioxidant
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Ingredient Facts
Hydroxyacetophenone
AKA: 4'-Hydroxyacetophenone, 99-93-4, 1-(4-Hydroxyphenyl)ethanone, 4-Hydroxyacetophenone, P-HYDROXYACETOPHENONE, 4-Acetylphenol, P-Hydroxyphenyl methyl ketone, Ethanone, 1-(4-hydroxyphenyl)-, Methyl p-hydroxyphenyl ketone, Para-Hydroxyacetophenone
Antioxidant · Antioxidant · EWG: 1
Synthetic
Antioxidant
Safety Concern
Clean
Ethanone, 1-(4-hydroxyphenyl)-,p-Hydroxyacetophenone
Solubility Practically insoluble or insoluble in water
Formula
C8H8O2
Mol. Weight
136.15
CAS #
99-93-4
Form
Powder
State
Dry Powder; Other Solid
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Neutralizes Free Radicals
Traditional Use
Developed as a modern synthetic preservative and antioxidant in the late 20th century for use in cosmetic formulations, created to replace some natural preservatives with improved stability.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
3 Piece Classic Suncare Travel Set
COOLA
C Complex Serum
Josh Rosebrook
Hydrating Sunscreen Lotion - Peach Blossom
COOLA
ten18 Lash Amplifying Mascara
Exa Beauty
Spectator Sport Mascara
Gen See
Golden Hour Body Serum
Ursa Major
Royal Tulip Hydrating Bi-Phase Tonic
Bloom Effects
Bright Start Retinol Alternative Eye Cream
ILIA Beauty
The Cleanse Soft Foaming Cleanser
ILIA Beauty
Dream Bio-Retinol Body Serum
Credo Beauty
SuperSerum Hydrating Mist
RMS Beauty
The New Skincare Lineup
RMS Beauty
Golden Hour Body Serum
Credo Beauty
Vital Spring Hydration Mask
Credo Beauty
Suncare Travel Essentials Set
COOLA
The Body Tool
Nécessaire
The Body Treatment Duo
Nécessaire
GoGo Cooling Shimmer Eyeshadow
Tower 28 Beauty
Vital Spring Hydration Mask
Ursa Major
Final Report: Safety Assessment of Hydroxyacetophenone as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Hydroxyacetophenone
European Commission
EU Cosmetic Ingredient Database (CosIng)
Hydroxyacetophenone
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Establishing biosynthetic pathway for the production of p-hydroxyacetophenone and its glucoside in Escherichia coli.
Lu L, Wang X, Zhou L, Liu Q, Zhang G et al.
Metabolic engineering, 2023
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR