murphyHydroxypropyl Cyclodextrin
Synthetic
Skin Conditioner
Clean
OriginDerived from natural plant starches, primarily corn, potato, or tapioca sources through selective harvesting and processing. Synthesized by chemically bonding hydroxypropyl groups to cyclodextrin molecules through etherification reactions.
.beta.-Cyclodextrin, 2-hydroxypropyl ethers
Formula
C39H66O31
Mol. Weight
1030.90
CAS #
128446-33-3, 128446-35-5
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Dermal Absorption 0.02–24%
2 animal studies in the CIR safety assessment (CIR 680)
Concentration Guide
Leave-on0.00001–2%
Rinse-off0.02–0.1%
0%50%100%
CIR reported use · 2013 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR