Isobutane

AKA: 2-Methylpropane, 75-28-5, Trimethylmethane, 1, 1-Dimethylethane, Iso-butane, R 600a, Caswell No. 503A, R-600a, HSDB 608
Synthetic
Not Clean
OriginIsobutane is a four-carbon alkane belonging to the saturated hydrocarbon family derived from crude oil refining. It is produced through the catalytic cracking and isomerization of longer-chain hydrocarbons during petroleum processing.
Isobutane, less than 0.1% w/w butadiene
Solubility Slight (NIOSH, 2024)
Formula
C4H10
Mol. Weight
58.12
CAS #
75-28-5
Form
Liquid
State
Isobutane is a colorless gas with a faint petroleum-like odor. It is shipped as a liquefied gas under its vapor pressure. Contact with the liquid can cause frostbite. It is easily ignited. The vapors
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Propellant
Dispenses Product
Locks In Moisture
Propels product from container
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
7
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Eye Irritant in Testing
1 study / 1 irritating / reactions mild (CIR 234)
Skin Irritant in Testing
1 study / 1 irritating / reactions mild to moderate (CIR 234)
Concentration Guide
Leave-on0.26–98%
Rinse-off0.53–4.5%
0%50%100%
CIR reported use · 2022 survey
Regulatory Agencies
🧂Conflict of interest.
Verified Jun 2026 · 🧪 = conflict
Data: PubChem · CosIng · EWG · CIR
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