Isostearyl Palmitate

AKA: Isooctadecyl palmitate, 72576-80-8, Hexadecanoic acid, Isooctadecyl ester, Isooctadecyl hexadecanoate, PELEMOL I-1816, PROTACHEM ISP, JEECHEM ISP
Plant-Derived
Emollient
Skin Conditioner
Clean
OriginDerived from palm and coconut oils through hydrogenation and esterification of fatty acids and alcohols. Synthesized by combining isostearyl alcohol with palmitic acid through esterification reaction.
The CIR Expert Panel concluded that the alkyl esters, listed subsequently, are safe in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating.
Formula
C34H68O2
Mol. Weight
508.90
CAS #
72576-80-8
Form
Liquid
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Binding
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
Leave-on0.2–17%
Rinse-off0.5–8%
0%50%100%
CIR reported use · 2012 survey
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR