Magnolol

AKA: 528-43-8, 5'-Diallyl-2, 2'-dihydroxybiphenyl, Dehydrodichavicol, 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol, 4-allyl-2-(5-allyl-2-hydroxy-phenyl)phenol, FEMA NO. 4559
Synthetic
Skin Conditioner
Synthetic
Clean
Magnolol has been reported in Magnolia henryi, Magnolia officinalis, and other organisms with data available.
Solubility Slightly soluble in water; soluble in DMSO
Formula
C18H18O2
Mol. Weight
266.30
CAS #
528-43-8
Form
Powder
State
White powder; Bitter aroma
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Antioxidant Protection
Neutralizes Free Radicals
Traditional Use
This is the CAS number for salicylic acid. First isolated from willow bark in the 1800s, salicylic acid became a cornerstone of acne treatment in the 20th century after its exfoliating and antibacterial properties were scientifically validated.
EWG
1
CIR
Safe
Pregnancy
Caution
CIR Safety Findings
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Caution
The paper trail
🔬Peer-reviewed1 paper
⚖️Regulatory0 listings
🛡️Safety-assessed1 review
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR