Mannose

AKA: (2S, 3S, 4R, 5R)-2, 3, 4, 5, 6-pentahydroxyhexanal, Demannose, CERC-802, GlyTouCan:G95531HX, 3458-28-4, Aldehydo-D-mannose, 31103-86-3
Synthetic
Humectant
Clean
OriginMannose is a six-carbon aldose sugar belonging to the monosaccharide chemical family, typically synthesized from glucose or fructose. It is produced through isomerization reactions that convert glucose into mannose using alkaline conditions or enzymatic catalysts.
Aldehydo-D-mannose is the D-enantiomer of aldehydo-mannose. It is a D-mannose and an aldehydo-mannose. It is an enantiomer of an aldehydo-L-mannose.
Formula
C6H12O6
Mol. Weight
180.16
CAS #
3458-28-4
Form
Powder
State
White hygroscopic powder; [Alfa Aesar MSDS]
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
1 study / 1 not irritating (CIR 657)
Not a Sensitizer
1 study / 1 not sensitizing (CIR 657)
Concentration Guide
Leave-on5%
Rinse-offNot reported
0%50%100%
CIR reported use · report published 2019
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR