Mannose
molecular structure · PubChem
AKA: (2S, 3S, 4R, 5R)-2, 3, 4, 5, 6-pentahydroxyhexanal, Demannose, CERC-802, GlyTouCan:G95531HX, 3458-28-4, Aldehydo-D-mannose, 31103-86-3
Synthetic
Humectant
Clean
Aldehydo-D-mannose is the D-enantiomer of aldehydo-mannose. It is a D-mannose and an aldehydo-mannose. It is an enantiomer of an aldehydo-L-mannose.
Effective at 4.7%
Formula
C6H12O6
Mol. Weight
180.16
CAS #
3458-28-4
Form
Powder
State
White hygroscopic powder; [Alfa Aesar MSDS]
Functions
Humectant
A moisture magnet. Pulls water from the air and deeper skin layers up to the surface to keep skin plump and hydrated.
Locks In Moisture
Traditional Use
A simple sugar identified in the late 19th century and found naturally in various plants and fruits. Adopted in modern skincare formulations in recent decades as a humectant and skin hydration agent, though no significant historical cosmetic use exists.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
0.0005%
9.4%
0%13%
Reported use
CIR reported use: 0.0005-9.4 | 0.3-0.5
Regulatory Agencies
Skin Types
●all-skin-types
Best For
Dehydration
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR