Methoxyisopropyl Acetate

Methoxyisopropyl Acetate 1
molecular structure · PubChem CID 7946
AKA: Propylene glycol methyl ether acetate, PGMEA cpd, 1-Methoxy-2-propyl acetate, 108-65-6, 1-methoxypropan-2-yl acetate, Propylene glycol monomethyl ether acetate, 2-Acetoxy-1-methoxypropane, 1-Methoxy-2-acetoxypropane
Synthetic
Solvent
Not Clean
OriginSynthesized from propylene glycol and acetic acid through esterification chemistry. Produced via catalytic reaction between the alcohol and acid precursors under controlled conditions.
2-methoxy-1-methylethyl acetate
Solubility In water, 1.98X10+5 mg/L at 25 °C
Formula
C6H12O3
Mol. Weight
132.16
CAS #
108-65-6
Form
Liquid
State
Propylene glycol methyl ether acetate is a colorless liquid with a sweet ether-like odor. (USCG, 1999)
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Solvent
Dissolves other ingredients so they distribute evenly in the formula. Often the invisible "base" everything else is mixed into.
Dissolves Ingredients
Dissolves other ingredients
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
1 study / 1 not sensitizing (CIR 355)
Mixed Skin Irritation Results
2 studies / 1 mixed / 1 not irritating / reactions slight (CIR 355)
Eye Irritant in Testing
2 studies / 2 irritating / reactions slight to moderate (CIR 355)
Concentration Guide
CIR lists it as not reported to be in use.
CIR · 2003 survey
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR