Methyl Glycyrrhizate

AKA: 104191-95-9, GAMME, Glycyrrhizic acid methyl ester, (2S, 3S, 4S, 5R, 6R)-6-[(2S, 3R, 5S, 6S)-2-[[(3S, 4aR, 6aR, 6bS, 8aS, 11S, 12aR, 14aR, 14bS)-11-methoxycarbonyl-4, 4, 6a, 6b, 8a, 11, 14b-heptamethyl-14-oxo-2, 3, 4a, 5, 6, 7, 8, 9, 10, 12, 12a, 14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxylato-4, 5-dihydroxyoxan-3-yl]oxy-3, 5-trihydroxyoxane-2-carboxylate

Synthetic

Fragrance

Not Clean

alpha-d-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-o-beta-d-glucopyranuronosyl-, methyl ester; Glycyrrhizic acid methyl ester

Formula

C43H62O16-2

Mol. Weight

834.90

CAS #

104191-95-9

Form

Powder

Functions

Fragrance

Added for scent. Can be natural or synthetic. Common irritant and allergen — one of the top reasons people react to products.

Brightens uneven skin tone

Evens pigmentation

Quells irritation

Traditional Use

Derived from licorice (Glycyrrhiza glabra), which has been used in Traditional Chinese Medicine and Ayurveda for over 2,000 years for skin soothing and anti-inflammatory benefits. The methylated form was developed to improve stability in modern cosmetic formulations.

EWG

CIR

Safe as used

Pregnancy

Yes

CIR Safety Findings

Not an Irritant

medical-approval

all-shades-safe

Regulatory Status

USA✔ permitted

EU⚠ restricted

JAPAN⚠ restricted

CANADA⚠ restricted

Regulatory Agencies

EWG CIR FDA EU COSING Health Canada

Skin Types

●all-skin-types

Best For

Irritation

Pregnancy & Breastfeeding Safe

Yes

The paper trail

🔬Peer-reviewednone on file

⚖️Regulatory1 listing →

🛡️Safety-assessed2 reviews →

Counts, not a verdict. A listing isn't a study. The trail, you decide.

Verified Jun 2026

Data: PubChem · CosIng · EWG · CIR