Methyl Thioglycolate
molecular structure · PubChem
AKA: 2365-48-2, Methyl mercaptoacetate, Methyl 2-mercaptoacetate, Thioglycolic acid methyl ester, Methylthioglycolate, Acetic acid, Methyl ester, Methanethiol, Methylmercaptoacetate
Synthetic
Not Clean
Based on the available data, the CIR Expert Panel concluded that ... Methyl Thioglycolate is safe for use in hair straighteners, permanent waves, tonics, dressings, and so forth, wave sets, other non-coloring hair products, and hair dyes and colors, as described in this safety assessment, at concentrations up to 15.2% (as Thioglycolic Acid). Hairdressers should avoid skin contact and minimize consumer skin exposure.
Formula
C3H6O2S
Mol. Weight
106.15
CAS #
2365-48-2
Form
Liquid
State
Colorless liquid with a stench; [MSDSonline]
Functions
Hair Waving Or Straightening
Anti-Aging Benefits
Antioxidant Protection
Reduces Inflammation
Changes hair texture
Traditional Use
Developed in the mid-20th century as a chemical depilatory and permanent wave setting agent. Created to replace safer but less effective historical hair-removal methods like sulfides and lyes.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR