Neopentyl Glycol Diethylhexanoate

AKA: 28510-23-8, NEOPENTYL GLYCOL DIOCTANOATE, Neopentyl glycol di(2-ethylhexoate), Neopentyl glycol di(2-ethylhexanoate), Neopentyl glycol bis(2-ethylhexanoate), SCHERCEMOL NGDO, KAK-NDO
Synthetic
Emollient
Skin Conditioner
Clean
OriginDerived from neopentyl glycol and ethylhexanoic acid, members of the synthetic alcohol and carboxylic acid families. Synthesized through esterification, combining neopentyl glycol with ethylhexanoic acid using acid catalysts.
2,2-Dimethyl-1,3-propanediyl diethylhexanoate
Formula
C21H40O4
Mol. Weight
356.50
CAS #
28510-23-8
Form
Liquid
State
Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
1 study / 1 not irritating (CIR 735)
Not a Sensitizer
1 study / 1 not sensitizing (CIR 735)
Not an Eye Irritant
1 study / 1 not irritating (CIR 735)
Concentration Guide
Leave-on0.9–57%
Rinse-off1.5–11%
0%50%100%
CIR reported use · 2016 survey
Regulatory Status
USA✔ permitted
CANADA✔ permitted
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR