Neopentyl Glycol Diisononanoate

Neopentyl Glycol Diisononanoate 1
molecular structure · PubChem CID 58240623
AKA: NPDIN, Symmollient L 177205, 27841-07-2, 1, 3-Bis(3, 5, 5-trimethylhexanoyloxy)-2, 2-dimethylpropane, 2, 2-Dimethylpropane-1, 3-diol di-3, 5-trimethylhexanoate, 3-Propanediol, Bis(3, 5-trimethylhexanoate), Hexanoic acid, 2-dimethyl-1, 3-propanediyl ester
Synthetic
Emollient
Skin Conditioner
Not Clean
OriginDerived from neopentyl glycol and isononanoic acid, members of the synthetic ester chemical family. Synthesized through esterification reaction between neopentyl glycol and branched isononanoic acid.
Neopentyl Glycol Diisononanoate is a cosmetic ingredient used as skin conditioning - emollient. Also known as NPDIN. Assessed as safe by the CIR.
Formula
C23H44O4
Mol. Weight
384.60
CAS #
-
Form
Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Locks In Moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
2 studies / 2 not irritating (CIR 558)
Not a Sensitizer
2 studies / 2 not sensitizing (CIR 558)
Eye Irritant in Testing
1 study / 1 irritating / reactions minimal (CIR 558)
Concentration Guide
Leave-on1.3%
Rinse-off2–5%
0%50%100%
CIR reported use · 2016 survey
Regulatory Status
USA✔ permitted
CANADA✔ permitted
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR