N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate

N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate 1
molecular structure · PubChem CID 93296
AKA: 54381-16-7, N-Bis(2-hydroxyethyl)-p-phenylenediamine sulphate, Ethanol, Sulfate (1:1) (salt), COLOREX NNBIS, JAROCOL BHP, (p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate, Sulfate (salt)
Synthetic
Not Clean
OriginSynthesized from p-phenylenediamine, a benzene-derived aromatic amine compound, through chemical oxidation and sulfation processes. Produced by sulfonating the dihydroxyethyl-substituted phenylenediamine base to create the stable sulfate salt form.
(p-Ammoniophenyl)bis(2-hydroxyethyl)ammonium sulphate
Formula
C10H18N2O6S
Mol. Weight
294.33
CAS #
54381-16-7
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Allergen Warning
⚠️ PPD (Hair Dye)
Functions
Hair Dyeing
Wound Healing
Moisturizing
Strengthens Barrier
Colors hair
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
6
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not Phototoxic
Animal test found no phototoxicity in the CIR safety assessment (CIR 115)
Sensitizer in Testing
1 study / 1 sensitizing (CIR 115)
Skin Irritant in Testing
1 study / 1 irritating (CIR 115)
Concentration Guide
Leave-onNot reported
Rinse-off0.006–1.3%
0%50%100%
CIR reported use · 2022 survey
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR