murphyNonoxynol-2
AKA: 20427-84-3, 4-Nonylphenol diethoxylate, 243-816-4, 2-[2-(4-Nonylphenoxy)ethoxy]ethanol, 9016-45-9
Synthetic
Cleanser
Not Clean
OriginDerived from nonylphenol, a synthetic compound in the alkylphenol ethoxylate chemical family. Synthesized through ethoxylation of nonylphenol with ethylene oxide under catalytic conditions.
Poly(oxy-1,2-ethanediyl), .alpha.-(dinonylphenyl)-.omega.-hydroxy-, phosphates (24 mol EO average molar ratio)
Solubility >1000 mg/l
Formula
C19H32O3
Mol. Weight
308.50
CAS #
39464-64-7
Form
Liquid
State
Liquid; Dry Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Removes Impurities
Cleansing Surfactant
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory0 listings
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Mixed Eye Irritation Results
1 study / 1 mixed / reactions minimal (CIR 695)
Skin Irritant in Testing
3 studies / 3 irritating / reactions slight to severe (CIR 212 and 695)
Mixed Sensitization Results
2 studies / 1 sensitizing / 1 not sensitizing (CIR 695)
Dermal Absorption 0.57%
in vitro / heat-separated human epidermal membrane / leave-on protocol / 10% w/w in isopropyl alcohol (15 ul) / 48 h / receptor media analysed by HPLC (CIR 44)
Concentration Guide
CIR's newest survey reports no concentration of use.
CIR · 2014 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR