Nonoxynol-50

Nonoxynol-50 molecular structure
molecular structure · PubChem
AKA: Nonoxynol 50, POE(50) nonylphenol, Nonylphenol ethoxylate 50
Synthetic
Skin Conditioner
Not Clean
Nonoxynol-50 is a cosmetic ingredient. Assessed as safe by the CIR.
Form
Liquid
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Traditional Use
Synthetic nonionic surfactant with no traditional use history. Developed for modern cosmetic formulations to enhance product stability and texture.
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
medical-approval
all-shades-safe
Moderate Irritant
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory0 listings
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: CosIng · EWG · CIR