Nonoxynol-8

AKA: 41506-14-3, Octaethylene glycol mono(p-nonylphenyl) ether, Nonylbenzene-PEG8-OH, 23-(4-Nonylphenoxy)-3, 6, 9, 12, 15, 18, 21-heptaoxatricosan-1-ol, Rokafenol N-8, 27177-05-5, 23-(Nonylphenoxy)-3
Synthetic
Cleanser
Not Clean
OriginDerived from ethylene oxide and nonylphenol, both petroleum-derived synthetic compounds. Synthesized through ethoxylation, where ethylene oxide chains are added to nonylphenol.
Poly(oxy-1,2-ethanediyl), .alpha.-(dinonylphenyl)-.omega.-hydroxy-, phosphate, (8 mol EO average molar ratio)
Formula
C31H56O9
Mol. Weight
572.80
CAS #
39464-64-7
Form
Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Removes Impurities
Cleansing Surfactant
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory0 listings
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Skin Irritant in Testing
1 study / 1 irritating / reactions mild to moderate (CIR 695)
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2015
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
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