Palmitoyl Arginine

Palmitoyl Arginine 1
Palmitoyl Arginine 2
AKA: N2-(1-Oxohexadecyl)-L-arginine, 58725-47-6, N-Palmitoyl-L-arginine, AMISAFE AP-01, L-Arginine
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Not Clean
L-Arginine, N(2)-hexadecanoyl-
Formula
C22H44N4O3
Mol. Weight
412.60
CAS #
58725-47-6
Form
Powder
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
A palmitic acid-amino acid conjugate synthesized for modern skincare, designed to deliver the conditioning properties of palmitic acid alongside the skin-beneficial properties of the amino acid arginine.
EWG
3
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR