Palmitoyl Arginine

Palmitoyl Arginine 1
molecular structure · PubChem CID 11223678
AKA: N2-(1-Oxohexadecyl)-L-arginine, 58725-47-6, N-Palmitoyl-L-arginine, AMISAFE AP-01, L-Arginine
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Not Clean
OriginDerived from the amino acid arginine and palmitic acid, both obtained through synthetic or biotechnological production. Synthesized through amidation, chemically bonding palmitic acid to arginine's amino group.
L-Arginine, N(2)-hexadecanoyl-
Formula
C22H44N4O3
Mol. Weight
412.60
CAS #
58725-47-6
Form
Powder
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
3
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2017
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR