AKA: 171263-26-6, Palmitoyl hexapeptide-12 [INCI], N-Palmitoyl-val-gly-val-ala-pro-gly, Glycine, 2-((S)-1-((2S, 5S, 11S)-5, 11-Diisopropyl-2-methyl-4, 7, 10, 13-tetraoxo-3, 6, 9, 12-tetraazaoctacosan-1-oyl)pyrrolidine-2-carboxamido)acetic acid, 2-[[(2S)-1-[(2s)-2-[[(2s)-2-[[2-[[(2s)-2-(hexadecanoylamino)-3-methylbutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid
WHAT IS IT? Plant-Derived Synthetic
Skin Conditioner
Clean
Origin Native to Unknown. Derived from palmitic acid and synthetic hexapeptide-12, a chain of six amino acids. Synthesized through peptide coupling reactions bonding the palmitoyl chain to the hexapeptide sequence.
Glycine, N-(1-oxohexadecyl)-L-valylglycyl-L-valyl-L-alanyl-L-prolyl-
IS IT FOR ME? Pregnancy & Breastfeeding Safe
Yes
WHAT’S IT DO? Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Boosts collagen production
CAN I TRUST THIS? The paper trail
🛡️ Safety-assessed 2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
IS IT CLEAN? CIR Safety Findings
Not a Sensitizer
1 study / 1 not sensitizing (CIR 633)
Mixed Eye Irritation Results
2 studies / 1 mixed / 1 not irritating / reactions moderate (CIR 633)
Mixed Skin Irritation Results
3 studies / 1 mixed / 2 not irritating / reactions moderate (CIR 633)
Concentration Guide
0% 50% 100%
CIR reported use · 2014 survey
Regulatory Status
JAPAN ⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
murphy
