Palmitoyl Isoleucine
molecular structure · PubChem
AKA: 54617-29-7, Voluform, N-Palmitoyl-L-isoleucine, L-Isoleucine
Synthetic
Barrier Support
Amino Acid
Clean
L-Isoleucine, N-(1-oxohexadecyl)-
Formula
C22H43NO3
Mol. Weight
369.60
CAS #
54617-29-7
Form
Powder
Functions
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Nourishes & Protects
Traditional Use
A synthetic amino acid conjugate created by attaching palmitic acid to isoleucine. Developed as a modern conditioning agent to improve skin texture and moisture retention.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
Industry max
Industry typically uses up to 0.07% in leave-on products (51 products reported). Source: CIR Safety Assessment (CIR Seq 607).
Regulatory Agencies
Skin Types
●all-skin-types
Best For
Loss of Elasticity
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR