Palmitoyl Isoleucine

Palmitoyl Isoleucine 1
molecular structure · PubChem CID 14993927
AKA: 54617-29-7, Voluform, N-Palmitoyl-L-isoleucine, L-Isoleucine
Synthetic
Barrier Support
Clean
OriginDerived from palmitic acid and the amino acid isoleucine, both synthetically sourced or extracted from natural oils. Synthesized through amide bond formation coupling palmitic acid with isoleucine via esterification or condensation reaction.
L-Isoleucine, N-(1-oxohexadecyl)-
Formula
C22H43NO3
Mol. Weight
369.60
CAS #
54617-29-7
Form
Powder
Skin Types
●all-skin-types
Best For
Loss of Elasticity
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Nourishes & Protects
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2017
Regulatory Status
USA✔ permitted
CANADA✔ permitted
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR