Palmitoyl Oligopeptide

AKA: 147732-56-7, Palmitoyl Tripeptide-1, L-Lysine, Pal-val-gly-val-ala-pro-gly-oh, (2S)-6-amino-2-[(2S)-2-(2-hexadecanamidoacetamido)-3-(1H-imidazol-4-yl)propanamido]hexanoic acid, (2S)-6-amino-2-((2S)-2-(2-hexadecanamidoacetamido)-3-(1H-imidazol-4-yl)propanamido)hexanoic acid, BIOPEPTIDE CL
Synthetic
Cleanser
Skin Conditioner
Amino Acid
Clean
Palmitoyl Oligopeptide is the product obtained by the reaction of palmitic acid with either a tripeptide consisting of gly-his-lys, or a hexapeptide consisting of val-gly-val-ala-pro-gly.The INCI Name, Palmitoyl Oligopeptide, originally developed in 1994, was designated with a retired status in 2013. For an interim period of time, trade name assignments formerly published with the name Palmitoyl Oligopeptide will be retained in the retired monograph, and also published with the new name assignme
Formula
C30H54N6O5
Mol. Weight
578.80
CAS #
147732-56-7
Form
Powder
Functions
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Boosts collagen production
Reduces fine lines
Traditional Use
A synthetic peptide created by chemically linking palmitic acid to short chains of amino acids. Developed in the late 20th century as an anti-aging ingredient designed to mimic peptide signaling in skin.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUpermitted
JAPANpermitted
CANADApermitted
Skin Types
all-skin-types
Best For
Wrinkles
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper
⚖️Regulatory1 listing
🛡️Safety-assessed2 reviews
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR