Palmitoyl Proline
molecular structure · PubChem
AKA: 59441-32-6, 1-(1-Oxohexadecyl)-L-proline, L-Proline, SEPIFEEL ONE, N-PALMITOYL-L-PROLINE, PALMITOYL PROLINE [INCI]
Synthetic
Skin Conditioner
Hair Care
Amino Acid
Clean
The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Palmitoyl Proline...
Formula
C21H39NO3
Mol. Weight
353.50
CAS #
59441-32-6
Form
Powder
Functions
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
A synthetic amino acid conjugate made by attaching palmitic acid to proline. Designed as a modern skincare ingredient to improve hydration and support skin firmness.
Skin Types
●all-skin-types
Best For
Loss of Elasticity
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR