murphyPanthenyl Ethyl Ether
AKA: 667-83-4, ORISTAR PEE, RITAPAN EE, (+)-PANTOTHENYL ETHYL ETHER, Butanamide, Pantothenyl ethyl ether
Synthetic
Skin Conditioner
Vitamin
Clean
OriginDerived from panthenol (provitamin B5) and ethylene glycol as starting materials from petrochemical sources. Synthesized through esterification reaction linking panthenol to ethyl ether functionality.
found in hair lotion; causes dermatitis; structure given in first source
Formula
C11H23NO4
Mol. Weight
233.30
CAS #
667-83-4
Form
Liquid
Skin Types
●all-skin-types
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Reduces Static
Conditions Hair
Reduces flyaways
Softens and detangles hair
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory0 listings
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Insufficient
Pregnancy
—
CIR Safety Findings
Not a Sensitizer
2 studies / 2 not sensitizing (CIR 737)
Not an Eye Irritant
1 study / 1 not irritating (CIR 737)
Mixed Skin Irritation Results
3 studies / 2 irritating / 1 not irritating / reactions slight to moderate (CIR 737)
Concentration Guide
Leave-on0.001–2%
Rinse-off0.005–0.5%
0%50%100%
CIR reported use · 2015 survey
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR