Phosphatidylserine
molecular structure · PubChem
AKA: Phosphotidylserine, Distearoylphosphatidylserine, 1446756-47-3, (2S)-2-amino-3-[[(2R)-2, 3-di(octadecanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid, Phosphatidyl Serines, Serines, Serine Phosphoglycerides
Synthetic
Emulsifier
Skin Conditioner
Barrier Support
Hair Care
Plant Oil
Clean
Fatty acid diglycerides, phosphate monoesters, 2-amino-2-carboxyethyl ester
Formula
C42H82NO10P
Mol. Weight
792.10
CAS #
1446756-47-3
Form
Powder
State
Solid
Functions
Emulsion Stabilising
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Nourishes & Protects
Traditional Use
A naturally occurring phospholipid found in cell membranes; discovered in the 20th century. Used in modern cosmetics as a skin-conditioning ingredient and potential anti-aging agent.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
Industry max
Industry typically uses up to 2.0% in leave-on products (9 products reported). Source: CIR Safety Assessment (CIR Seq 607).
Regulatory Agencies
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewed1 paper →
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR