murphyPolyaminopropyl Biguanide
AKA: N'-[6-[(N'-methylcarbamimidoyl)amino]hexyl]ethanimidamide, Lavasorb, Mediscrub, Poly (hexamethylene biguanide), Polyhexamethylene Biguanidine HCl
Synthetic
Preservative
Not Clean
OriginSynthesized from guanidine and diamine compounds through organic chemistry pathways. Produced via condensation reactions combining biguanide precursors with polyamine chains.
Poly(hexamethylenebiguanide) hydrochloride [1];poly(iminoimidocarbonyl)iminohexamethylene hydrochloride [2];Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) [3];- [4]
CAS #
32289-58-0, 27083-27-8, 28757-47-3, 133029-32-0
Form
Liquid
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
Functions
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Preserves Formula
Locks In Moisture
Fights Bacteria
Prevents microbial growth
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
Not Phototoxic
Animal test and Human test found no phototoxicity in the CIR safety assessment (CIR 738)
Mixed Skin Irritation Results
12 studies / 6 irritating / 1 mixed / 5 not irritating / reactions slight to severe (CIR 738)
Mixed Sensitization Results
10 studies / 3 sensitizing / 1 mixed / 6 not sensitizing / plus 4 case reports (CIR 738)
Mixed Eye Irritation Results
5 studies / 4 irritating / 1 not irritating / reactions slight to severe (CIR 738)
Dermal Absorption 0.001–0.17%
5 lab (in vitro) studies in the CIR safety assessment (CIR 738)
Concentration Guide
Leave-on0.00001–0.2%
Rinse-off0.00025–0.1%
0%50%100%
Reg. limit 0.1%
CIR reported use · report published 2020
EU/SCCS limit: 0.1% in cosmetic products. Opinion: SCCS/1581/16
Regulatory Agencies
Verified Jun 2026
Data: CosIng · EWG · CIR