Polyglyceryl-10 Isostearate
molecular structure · PubChem
AKA: 133738-23-5, 2, 3-dihydroxypropyl 2, 3, 4, 5, 6-nonakis(2, 3-dihydroxypropyl)-16-methylheptadecanoate, OPKQRMPUGFJLOM-UHFFFAOYSA-N
Plant-Derived
Skin Conditioner
Plant Oil
Clean
1,2,3-Propanetriol, homopolymer, isooctadecanoates (1:1) (10 mol glycerol average molar ratio)
Effective at 1.31%
Formula
C48H96O22
Mol. Weight
1025.30
CAS #
133738-23-5
Form
Liquid
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
A synthetic ester developed in the late 20th century as a gentle, modern emulsifier for cosmetics. Designed to replace harsher traditional surfactants while providing better skin compatibility.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
ewg-1
medical-approval
pregnancy-nursing-safe
all-shades-safe
Concentration Guide
0.62%
2.0%
0%3%
Reported use
CIR reported use: 1-2 | 0.62-1.8
Regulatory Agencies
Skin Types
●all-skin-types, gentle
Best For
General
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR