Polyglyceryl-10 Isostearate

AKA: 133738-23-5, 2, 3-dihydroxypropyl 2, 3, 4, 5, 6-nonakis(2, 3-dihydroxypropyl)-16-methylheptadecanoate, OPKQRMPUGFJLOM-UHFFFAOYSA-N
Plant-Derived
Skin Conditioner
Clean
OriginDerived from coconut, palm kernel, or vegetable oils as the primary starting material. Synthesized through polyesterification and polymerization of glycerin with isostearic acid.
1,2,3-Propanetriol, homopolymer, isooctadecanoates (1:1) (10 mol glycerol average molar ratio)
Formula
C48H96O22
Mol. Weight
1025.30
CAS #
133738-23-5
Form
Liquid
Skin Types
●all-skin-types, gentle
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
1 study / 1 not irritating (CIR 717)
Mixed Eye Irritation Results
2 studies / 1 irritating / 1 not irritating / reactions minimal (CIR 717)
Concentration Guide
Leave-on0.6%
Rinse-offNot reported
0%50%100%
CIR reported use · report published 2023
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR