Polyglyceryl-2 Diisostearate

AKA: Diglyceryl diisostearate, DERMOL DGDIS, MATSUNATE DI, RISOREX PGIS22, CITHROL PG 22IS, SALACOS 42V, COSMOL 42V, MATSUNATE MI-220
Plant-Derived
Cleanser
Emulsifier
Clean
Diester of diglycerol and isostearic acid
Formula
C42H82O7
Mol. Weight
699.10
CAS #
67938-21-0
Functions
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Emulsifier
Antioxidant Protection
UV Protection
Mixes Oil & Water
Traditional Use
Developed in the mid-20th century as a synthetic polyglyceryl ester emulsifier. Used in cosmetics to stabilize formulations and improve product texture.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USApermitted
EUrestricted
JAPANrestricted
CANADArestricted
Skin Types
all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing
🛡️Safety-assessed2 reviews
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR