Polyglyceryl-2 Sesquiisostearate

AKA: Diglyceryl diisostearate, DERMOL DGDIS, MATSUNATE DI, RISOREX PGIS22, CITHROL PG 22IS, SALACOS 42V, COSMOL 42V, MATSUNATE MI-220
Plant-Derived
Cleanser
Emulsifier
Clean
OriginDerived from vegetable oils such as coconut, palm kernel, or soybean through esterification of glycerin and isostearic acid. Synthesized by esterifying polyglycerol with isostearic acid through catalytic condensation reactions.
Isooctadecanoic acid, diester with oxydi(propanediol)
Formula
C42H82O7
Mol. Weight
699.10
CAS #
67938-21-0
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Emulsifier
Antioxidant Protection
UV Protection
Mixes Oil & Water
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
1 study / 1 not irritating (CIR 717)
Concentration Guide
Leave-on2.1–7.6%
Rinse-off1.1%
0%50%100%
CIR reported use · report published 2023
Regulatory Agencies
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR
murphy