Polyglyceryl-2 Tetraisostearate

AKA: Cithrol PG24IS, Salacos 44V, Cosmol 44V, S-FACE IS-204 P, 121440-30-0, PVQZOFSIXYDDHY-UHFFFAOYSA-N
Plant-Derived
Emollient
Cleanser
Emulsifier
Skin Conditioner
Clean
OriginDerived from polyglycerin and isostearic acid, both produced from plant oils or synthetic petroleum sources. Synthesized through esterification of polyglycerin with isostearic acid under controlled conditions.
Polyglyceryl-2 tetraisostearate consist of 1,2,3-Propanetriol, homopolymer, isooctadecanoates (1:4) (2 mol glycerol average molar ratio)
Formula
C78H150O9
Mol. Weight
1232.00
CAS #
121440-30-0
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Emulsion Stabilising
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Cleansing
Makes oil and water mix so dirt, makeup, and sunscreen can actually be washed away. The reason your face wash foams.
Locks In Moisture
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed2 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
Leave-on0.5–7%
Rinse-offNot reported
0%50%100%
CIR reported use · report published 2023
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR