murphyPolyquaternium-22
molecular structure · PubChem
Synthetic
Occlusive
Clean
OriginSynthesized from acrylamide and dimethylaminopropyl methacrylamide monomers, members of the synthetic polymer chemical family. Produced through free-radical polymerization and subsequent quaternization to create positively charged polymer chains.
2-Propenaminium, N,N-dimethyl-N-(2-propenyl)-, chloride, polymer with 2-propenoic acid
CAS #
53694-17-0
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Antistatic
Film Forming
Creates a physical seal on skin to lock moisture in and keep irritants out. The "slugging" ingredient — barrier protection.
Reduces Static
Creates Protective Barrier
Locks In Moisture
Reduces Inflammation
Fights Bacteria
Creates protective layer
Reduces flyaways
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed3 reviews →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Skin Irritant
2 studies / 2 not irritating (CIR 598)
Mixed Eye Irritation Results
2 studies / 1 irritating / 1 not irritating / reactions slight (CIR 598)
Concentration Guide
Leave-on0.4–0.5%
Rinse-off0.03–2%
0%50%100%
CIR reported use · 2011 survey
Regulatory Agencies
Verified Jun 2026
Data: CosIng · EWG · CIR