Polyquaternium-45

Polyquaternium-45 molecular structure
molecular structure · PubChem
Synthetic
Occlusive
Not Clean
OriginSynthesized from quaternary ammonium compounds derived from petroleum-based chemical feedstocks and polymeric precursors. Produced through polymerization and quaternization reactions to create a positively charged polymer chain.
Glycine, N-methyl-N-[2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl]-, polymer with 2-(dimethylamino)ethyl 2-methyl-2-propenoate, compound with dimethyl sulfate
CAS #
221225-18-9
Form
Powder
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
Functions
Antistatic
Film Forming
Creates a physical seal on skin to lock moisture in and keep irritants out. The "slugging" ingredient — barrier protection.
Hair Fixing
Reduces Static
Creates Protective Barrier
Creates protective layer
Reduces flyaways
Holds hair in place
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
EWG
4
CIR
Safe as used
Pregnancy
Yes
Concentration Guide
CIR lists it as not reported to be in use.
CIR · report published 2012
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Verified Jun 2026
Data: CosIng · EWG · CIR