Polyquaternium-45

Synthetic

Occlusive

Not Clean

Glycine, N-methyl-N-[2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl]-, polymer with 2-(dimethylamino)ethyl 2-methyl-2-propenoate, compound with dimethyl sulfate

CAS #

221225-18-9

Form

Powder

Functions

Antistatic

Film Forming

Creates a physical seal on skin to lock moisture in and keep irritants out. The "slugging" ingredient — barrier protection.

Hair Fixing

Reduces Static

Creates Protective Barrier

Creates protective layer

Reduces flyaways

Holds hair in place

Traditional Use

A synthetic polymer developed in the 2000s for cosmetic use. Designed to provide superior conditioning and styling benefits with improved sensory profile and compatibility in complex formulations.

EWG

CIR

Safe as used

Pregnancy

Yes

CIR Safety Findings

Not a Sensitizer

medical-approval

all-shades-safe

Regulatory Status

USA✔ permitted

EU⚠ restricted

JAPAN⚠ restricted

CANADA⚠ restricted

Regulatory Agencies

EWG CIR FDA EU COSING Health Canada

Skin Types

●all-skin-types

Best For

General

Pregnancy & Breastfeeding Safe

Yes

The paper trail

🔬Peer-reviewednone on file

⚖️Regulatory1 listing →

🛡️Safety-assessed1 review →

Counts, not a verdict. A listing isn't a study. The trail, you decide.

Verified Jun 2026

Data: CosIng · EWG · CIR