Polyurethane-27
molecular structure · PubChem
AKA: PU-27
Synthetic
Occlusive
Skin Conditioner
Barrier Support
Hair Care
Not Clean
Polyurethane-27 is a complex polymer that is formed by the reaction of Polyperfluoroethoxymethoxy Difluorohydroxyethyl Ether and isophorone diisocyanate (IPDI) to form a prepolymer. The prepolymer is further reacted with the triethylamine salt of 3-hydroxy-2-(hydroxymethyl)-2-methyl-1-propionic acid
CAS #
328389-91-9
Form
Powder
Functions
Film Forming
Creates a physical seal on skin to lock moisture in and keep irritants out. The "slugging" ingredient — barrier protection.
Hair Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Skin Protecting
Helps rebuild and strengthen your skin barrier — the invisible shield that keeps moisture in and irritants out. Essential after over-exfoliating or harsh weather.
Nourishes & Protects
Traditional Use
Modern synthetic polymer used in cosmetics for film-forming and conditioning purposes. Developed to improve product texture, stability, and protective properties.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Yes
The paper trail
🔬Peer-reviewednone on file
⚖️Regulatory1 listing →
🛡️Safety-assessed1 review →
Counts, not a verdict. A listing isn't a study. The trail, you decide.
Verified Jun 2026
Data: CosIng · EWG · CIR