Polyurethane-53

Synthetic

Skin Conditioner

Not Clean

OriginPolyurethane-53 is synthesized from polyols and diisocyanates, which are petroleum-derived chemical precursors. The compound is produced through step-growth polymerization, where diisocyanate monomers react with polyol compounds to form long-chain polymer chains.

Polyurethane-53 is a copolymer of poly(1,4-butanediol), isophorone diisocyanate and 2-hydroxypropyl acrylate

Skin Types

●all-skin-types

Best For

General

Pregnancy & Breastfeeding Safe

Yes

Functions

Nail Conditioning

A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.

Strengthens nails

The paper trail

🔬Peer-reviewednone on file

⚖️Regulatory1 listing →

🛡️Safety-assessed1 review →

Counts, not a verdict. A listing isn't a study. The trail, you decide.

EWG

CIR

Safe as used

Pregnancy

Yes

Concentration Guide

CIR lists it as not reported to be in use.

CIR · report published 2017

Regulatory Status

USA✔ permitted

EU⚠ restricted

JAPAN⚠ restricted

CANADA⚠ restricted

Regulatory Agencies

EWG CIR FDA EU COSING Health Canada

Verified Jun 2026

Data: CosIng · EWG · CIR